泛血管疾病是一组血管系统疾病，以动脉粥样硬化为共同病理特征，危害心、脑、肾、四肢等重要器官。具有起病隐匿、病程长、病情迁延不愈的特点，并且呈现动态发展过程，其病因具有多效性、稳健性和重塑性特性，从而使人体的健康状态和疾病过程呈现一种相互交织的网络形态。因此，需要打破还原论的静态思维，在研究策略上向系统生物学的复杂性思维转变。充分发挥多组学技术优势，以整合理念为核心，关注研究对象在基因组—暴露组—表型组多层次的相互作用，揭示疾病在全生命周期中不同阶段、不同组学层次间呈现的动态性、多效性、适应性的网络关联。将研究的视角从“单一疾病”转变为“多病”医学，以“疾病为导向”转变为“以人为导向”，从多维度、多层次、多时点的病因网络出发，探明泛血管疾病在发展过程中发挥关键作用的分子标志物集群。

The Hakka Earth building Pedigree-based Cohort (HEPC) was initiated in Nanjing County, Fujian Province, China, in 2015. HEPC recruited probands with the same surnames and then enrolled their first-degree and more distant relatives. According to the local genealogical booklets and family registry, pedigree structure was established. The heritability of cardiovascular traits was estimated, and the genotype–environment interaction was explored based on the pedigree and phenotype information. A total of 452 extended pedigrees consisting of 2818 family members were obtained in the baseline survey. The analysis showed that most of the cardiovascular traits presented a moderate level of heritability (0.263 to 0.799). Genotype–environment interaction analysis was performed to explore the potential interaction between genetic components and the nutritional exposures influencing the risk of cardiovascular traits.